Pharmacology-Therapeutics Review- Antifungal Therapy

The introduction of new antifungal agents in the past decades has transformed the management of topical fungal infections, onychomycosis and invasive mycoses to the point that drug toxicity is no longer the major limiting factor in treatment. Yet, many of these antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for pharmacokinetic drug-drug interactions and unusual toxicities associated with long-term use. This presentation reviews key pharmacological aspects of systemic antifungal agents as well as evolving strategies, such as pharmacokinetic-pharmacodynamic optimization and therapeutic drug monitoring, to improve the safety and efficacy of systemic antifungal therapy.

CME (Credits: 1.00)